What disease is related to adrenal insufficiency?
(A.) Celiac sprue
(B.) Addison’s disease
(C.) Cushing’s syndrome
Answer: (B.) Addison’s disease
Primary adrenal insufficiency, called Addison’s disease produces signs and symptoms that are related to a deficiency in aldosterone and cortisol. The most common complaints are weakness, fatigue, and abdominal pigmentation of the skin and mucous membranes. Hypotension, anorexia, and weight loss are additional common findings. Secondary adrenal insufficiency caused by long-term corticosteroid administration may cause a partial insufficiency that is limited to glucocorticosteroids. Treatment consists of replacement therapy with glucocorticoids and mineral corticoids. The prognosis is good with appropriate therapy.
Cushing’s syndrome on the other hand is related to the most common form of hyperadrenalism. We will find more questions and information related to this syndrome in a later post.
Celiac sprue, also known as celiac disease or gluten-sensitive enteropathy, is a chronic disorder of the digestive tract that results in an inability to tolerate gliadin, the alcohol-soluble fraction of gluten. Gluten is a protein commonly found in wheat, rye, and barley.
When patients with celiac sprue ingest gliadin, an immunologically mediated inflammatory response occurs that damages the mucosa of their intestines, resulting in maldigestion and malabsorption of food nutrients.
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